• br Conclusions br Acknowledgments br Introduction

  2024-12-02

  

  Conclusions Acknowledgments Introduction To die or not to die – that is the question. Christian de Duve created the word “autophagy” in 1960’s for the first time (Klionsky et al., 2016). The word “autophagy” was derived from the Greek roots “auto” (self) and “phagy” (eating) and referred to

• br Author contributions br Conflicts

  2024-12-02

  

  Author contributions Conflicts of interest The authors declare no competing financial interests. Acknowledgement This work was supported by grants from the Deutsche Forschungsgemeinschaft (Sonderforschungsbereich/Transregio 166–Project C1 and grant CA 1014/1-1 to D.C.) and the IZKF Würzbur

• It is well known that neurosteroids such as testosterone

  2024-12-02

  

  It is well-known that neurosteroids such as testosterone and their metabolites endogenously modulate neural excitability in animals and humans. Testosterone has protective effects against seizures induced by KA and PTZ (Frye et al., 2001b; Reddy, 2004b). Estrogens, on the other hand, have proconvuls

• Negative regulation of AR expression by NF B

  2024-12-02

  

  Negative regulation of AR expression by NFκB was also correlated with the ‘age-dependent desensitisation’ of androgen action in the rat liver (Supakar et al., 1995). In this case the binding site was mapped upstream of the gene to sequences −555 to −565 bp, that binds heterodimers of p65 and p50, as

• Introduction Pyometra is relatively common in

  2024-11-29

  

  Introduction Pyometra is relatively common in intact bitches and its diagnosis is aided by ultrasonography (Bigliardi et al., 2004), along with measurement of acute phase proteins and leucocyte (white blood cell, WBC) counts; assessment of these parameters during recovery may be helpful for monitor

• br Conflict of interest statement

  2024-11-29

  

  Conflict of interest statement Benign prostatic hyperplasia (BPH) is a highly complex process characterized by an increased number of epithelial and stromal Amphotericin B in the transition zone. , , Autopsy studies by McNeal detail the evolution of histological changes within these 2 cellula

• br Materials and methods br Results br

  2024-11-29

  

  Materials and methods Results Discussions Our results indicated that autophagy was suppressed in GECs under HAGG treatment, through Akt/mTOR-dependent pathways. Previous reports provided clues for the linkages between ICs and endothelial cell autophagy. Fujii and colleagues reported that se

• br Results br Discussion br Conclusion The flux

  2024-11-28

  

  Results Discussion Conclusion The flux of glucose into cytosolic short chain acyl-CoAs was maintained in pure beta Beta-Lapachone in the presence of inhibition of ATP citrate lyase with hydroxycitrate and also in a cell line with >90% ATP citrate lyase knockdown suggesting that a pathway o

• In addition to drawing attention to Ser

  2024-11-28

  

  In addition to drawing attention to Ser454 of ACL as a phosphosite that is regulated by both BDK and PPM1K, our phospho-proteomics screen identified several additional sites in other proteins. For example, Ser25, Ser29, and Ser79 of the lipogenic enzyme acetyl-coA carboxylase 1 (ACC1) were found to

• br Discussion Herein we demonstrate that mice deficient

  2024-11-28

  

  Discussion Herein, we demonstrate that mice deficient in L-12/15 LO are more sensitive to 3-NP-induced toxicity although a substantial individual variability in striatal lesion size in response to 3-NP in both genotypes was observed. This variability is not atypical; several studies demonstrate s

• Mechanistically it was soon realized that in undead cells Dr

  2024-11-28

  

  Mechanistically, it was soon realized that in undead cells, Dronc promotes the activation of Jun-N-terminal kinase (JNK) signaling as the major inducer of AiP [25], [28] (Fig. 2B,C). However, it has been unknown for a long time how active Dronc promotes JNK signaling. Recently, it was reported that

• Bran is a byproduct of flour milling

  2024-11-28

  

  Bran is a byproduct of flour milling, typically utilized as a valuable component of animal feeds. Because of its attractive technological and health-promoting properties, it Cy5 hydrazide (non-sulfonated) has also been increasingly used in food manufacturing as a source of dietary fiber. Indeed, wi

• Most intriguingly however there was

  2024-11-28

  

  Most intriguingly, however, there was no change in basal glutamatergic neurotransmission despite a loss of about half of the neuronal AMPAR population. Highest levels of ammonia did neither affect the amplitude nor the frequency of AMPAR mediated mEPSCs. As revealed by our recordings from somatic ou

• br Perspectives br Acknowledgments This investigation was su

  2024-11-28

  

  Perspectives Acknowledgments This investigation was supported by a Research Grant 2010/01385-5 from FAPESP (Sao Paulo Research Foundation, Brazil). P.F.S. was recipient of a CNPq (National Council for Scientific and Technological Development, Brazil) productivity grant. R.F.A. was recipient of

• br Materials and methods br Results and

  2024-11-28

  

  Materials and methods Results and discussion Conclusions In this study, for the first time to the best of our knowledge, the stability of pure hsALDH has been studied under various conditions. The enzyme exhibited low storage stability both at 4°C and 25°C, which could be improved to a good

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