• Gut-Brain Cholinergic Signaling in Microbiota-Mediated Seizu

  2026-06-30

  Jia et al. identify a gut-vagus-brain cholinergic pathway through which Bacteroides fragilis suppresses seizures in pediatric refractory epilepsy. Their translational work combines animal models and a clinical trial, revealing how microbiota-driven acetylcholine neurotransmitter signaling modulates neuronal excitability and opens new mechanistic avenues for microbiota-based therapies.

• Advancing mRNA Purification: Strategic Leverage in Cancer Re

  2026-06-29

  This thought-leadership piece explores how mechanistically precise eukaryotic mRNA isolation—anchored by Oligo (dT) 25 Beads—empowers translational researchers to decode complex regulatory axes in cancer, specifically highlighting the NSD1–PPARγ–PTEN pathway in endometrial cancer. Integrating biologic rationale, experimental strategies, and practical workflow guidance, the article delivers actionable insights and a visionary outlook for translational pipeline optimization.

• Mycophenolic Acid in Immunometabolism: Mechanisms and Protoc

  2026-06-29

  Explore how Mycophenolic acid, a potent dehydrogenase inhibitor, enables advanced modulation of immune responses in research. This article provides a deeper mechanistic analysis and practical assay guidance for immunometabolism studies.

• PP 1 (Src Family Tyrosine Kinase Inhibitor): Precision Tools

  2026-06-28

  Explore the scientific and translational impact of PP 1, a potent Src family tyrosine kinase inhibitor, in dissecting cancer and immune pathways. This in-depth article uniquely connects precision kinase modulation to advanced biomarker strategies in immunotherapy research.

• 4μ8C and the UPR: Precision Tools for ER Stress–Inflammation

  2026-06-27

  Explore how 4μ8C, a potent unfolded protein response inhibitor, enables advanced dissection of ER stress–driven inflammation and pyroptosis. This in-depth guide offers unique practical insights for cancer and disc degeneration research.

• Oligo (dT) 25 Beads: Streamlined Superparamagnetic mRNA Isol

  2026-06-26

  Oligo (dT) 25 Beads from APExBIO set a new benchmark in eukaryotic mRNA isolation by combining superparamagnetic precision with workflow versatility. Their high specificity for polyA tails and robust downstream compatibility empower researchers to accelerate discovery across transcriptomic and functional genomics studies.

• Machine Learning-Guided LNPs for mRNA Delivery to Microglia

  2026-06-26

  This study leverages supervised machine learning to design immunomodulatory lipid nanoparticles (LNPs) for targeted mRNA delivery to hyperactivated microglia. The findings highlight the potential of data-driven LNP optimization to modulate neuroinflammatory processes with high specificity, opening new strategies for mRNA therapeutics in neuroimmune disorders.

• Notch Inhibition Boosts Immunotherapy Response in TNBC Model

  2026-06-25

  Shen et al. (2024) demonstrate that pharmacologic Notch pathway inhibition reprograms the tumor immune microenvironment and markedly enhances the efficacy of immune checkpoint blockade in triple-negative breast cancer (TNBC). These findings reveal a mechanistic basis for combining Notch inhibitors with immunotherapy to suppress metastasis and improve therapeutic outcomes in aggressive TNBC.

• Lithium Drives Exosomal Wnt10a Secretion to Boost Osteogenes

  2026-06-25

  The referenced study reveals how lithium enhances bone regeneration by promoting Rab11a-mediated exosomal Wnt10a secretion and activating Wnt/β-catenin signaling in mesenchymal stem cells. These findings clarify the molecular mechanisms underpinning lithium-driven osteogenesis and provide a mechanistic framework for optimizing exosome-based therapies for bone repair.

• Dorsomorphin 2HCl: Precision AMPK Inhibitor Workflows in Met

  2026-06-24

  Dorsomorphin 2HCl empowers researchers to dissect AMPK and BMP signaling with reproducible, high-specificity inhibition, directly impacting studies from metabolic disease to osteogenesis and iron homeostasis. This article details optimized protocols, troubleshooting strategies, and the latest insights from gut-liver axis research, positioning APExBIO's Dorsomorphin 2HCl as an indispensable tool for translational investigations.

• Annexin V Enables Early In Vivo Detection of Cardiomyocyte D

  2026-06-23

  The reference study demonstrates that labeled recombinant human Annexin V detects early cardiomyocyte cell death in a mouse model of myocardial ischemia/reperfusion (I/R). This work establishes Annexin V as a sensitive in situ marker for phosphatidylserine externalization, with critical implications for mapping the temporal dynamics of apoptosis and evaluating cell death–blocking strategies in cardiac research.

• 2-Deoxy-D-glucose: Mechanistic Leverage for Metabolic Resear

  2026-06-23

  Explore how 2-Deoxy-D-glucose (2-DG) enables translational researchers to dissect and strategically manipulate cellular metabolism. This article connects the latest mechanistic insights on glycolysis inhibition, lactate signaling, and metabolic stress with actionable guidance for cancer, virology, and immunometabolic studies. We benchmark APExBIO’s 2-DG against the evolving scientific landscape, highlight protocol best practices, and offer a forward-looking perspective on cross-domain opportunities in metabolic therapeutics.

• Protease Inhibitor Cocktail (EDTA-Free, 200X in DMSO): Workf

  2026-06-22

  The Protease Inhibitor Cocktail (EDTA-Free, 200X in DMSO) is designed to prevent protein degradation during extraction and analysis workflows, especially where divalent cation compatibility is required. This article details how to integrate this broad-spectrum inhibitor into protein extraction, Western blotting, and co-immunoprecipitation workflows, while clarifying boundaries such as its inapplicability for metalloprotease inhibition. Use cases, limitations, and troubleshooting tips are provided for accurate and reproducible protein science.

• ABT-263 (Navitoclax): Precision Tools for Apoptosis Quantifi

  2026-06-22

  Discover how ABT-263 (Navitoclax) is transforming apoptosis quantification in cancer biology research. This article delves into advanced assay design, evidence-based metrics, and practical insights from recent systems biology breakthroughs.

• Pharmacogenomics of Chloroquine & Hydroxychloroquine: System

  2026-06-21

  This article reviews Biswas & Sukasem's systematic synthesis of pharmacogenomic evidence for chloroquine and hydroxychloroquine. Their analysis clarifies how cytochrome P450 genetic variability shapes drug safety and efficacy, underscoring the need for genotype-guided therapy and highlighting practical implications for drug development and personalized medicine.

8038 records 7/536 page Previous Next First page 上5页 678910 下5页 Last page